THE BIOAVAILABILITY OF CANNABIDIOL
The burgeoning market for CBD, driven by its growing popularity, has seen a wide range of products and usage options develop, as well as the emergence of scientific terms such as bioavailability, concentration and purity that can complicate consumer understanding and lead to mistakes in choice.
In other words, bioavailability refers to the rate of effectiveness of a substance after administration, quantifying its availability and rate of uptake by body tissue or the bloodstream.
Methods of administration such as ingestion, inhalation, or the application of cosmetics significantly influence the bioavailability rate, thereby altering the quantity of CBD that will ultimately need to be absorbed, the bioavailable amount.
Thus, the higher the bioavailability rate of a CBD product, the faster the effects will occur, and the less quantity will be required.
Medically, intravenous injection is considered 100% immediately bioaccessible.
Any other form of administration will be considered less available and will require larger quantities or higher concentrations.
Knowledge of bioavailability rates allows you to choose the most appropriate absorption method for your needs, precisely quantify the necessary doses, and optimize the dosage, leading to substantial savings.
INGESTION OF CBD ALLOWS CANNABINOIDS TO BE INTRODUCED INTO THE DIGESTIVE SYSTEM AND LIVER TO BE CONVERTED INTO ASSIMILABLE FORM.
But before this happens, a dialysis phenomenon occurs in the stomach, where metabolic enzymes perform filtration to eliminate chemical compounds and attempt to prevent the transfer of Cannabidiol into the bloodstream.
It also delays the assimilation of chemical compounds and the action of CBD, resulting in a slower release and delayed effects, which are more long-lasting.
The defensive reaction of our body destroys a portion of the molecules, requiring higher necessary doses.
Endocannabinoid receptors have also been found in muscles and nerves, justifying the interest of certain cosmetic products used by dermal application.
However, cannabinoids, including CBD, being hydrophobic and the skin barrier significantly reducing their effectiveness, topical application undoubtedly provides the lowest bioavailability. When mixed with other essential oils, the synergy of all components will facilitate the dispersion and effectiveness of cannabinoids.
Finally, combustion-based inhalation methods, the least discreet, and vaporization, the most expensive, offer the highest absorption rate of cannabinoids, as it is virtually instantaneous.
We strongly advise against combustion processes
We strongly advise against combustion processes, as the near-pyrolysis temperature of the furnace (400°C) will destroy the majority of terpenes (aromas and flavors) and eliminate 85% of inhaled cannabinoids.
MINIMUM TIME TO FEEL THE EFFECTS OF YOUR CBD
However, you may immediately feel the effects of associated pain-relieving ingredients such as capsaicin from peppers or phenols from green mint.
For long-lasting effects, ingestion with digestion of over an hour and slow release providing 4 to 8 hours of effects can be practical for organizing your schedule with time between intake and effects.
Sublingual ingestion provides a similar duration of effects, over 4 hours, but especially with faster action, its effectiveness will be felt in just 10 to 15 minutes.