Understanding CBD Bioavailability

When CBD is introduced into the body, it is metabolized in different ways depending on how it has been administered.

Methods of administration such as ingestion, inhalation, or the application of cosmetics significantly influence the bioavailability rate, thereby altering the quantity of CBD that will ultimately need to be absorbed, the bioavailable amount.

Thus, the higher the bioavailability rate of a CBD product, the faster the effects will occur, and the less quantity will be required.
Medically, intravenous injection is considered 100% immediately bioaccessible.
Any other form of administration will be considered less available and will require larger quantities or higher concentrations.

Knowledge of bioavailability rates allows you to choose the most appropriate absorption method for your needs, precisely quantify the necessary doses, and optimize the dosage, leading to substantial savings.

They are then directed into the bloodstream.

But before this happens, a dialysis phenomenon occurs in the stomach, where metabolic enzymes perform filtration to eliminate chemical compounds and attempt to prevent the transfer of Cannabidiol into the bloodstream.

It also delays the assimilation of chemical compounds and the action of CBD, resulting in a slower release and delayed effects, which are more long-lasting.

The defensive reaction of our body destroys a portion of the molecules, requiring higher necessary doses.

Precisely targeting specific areas, creams and lotions deliver active compounds to the nerves and muscles just beneath the skin, representing a growing trend in beauty and well-being.

However, cannabinoids, including CBD, being hydrophobic and the skin barrier significantly reducing their effectiveness, topical application undoubtedly provides the lowest bioavailability. When mixed with other essential oils, the synergy of all components will facilitate the dispersion and effectiveness of cannabinoids.

Finally, combustion-based inhalation methods, the least discreet, and vaporization, the most expensive, offer the highest absorption rate of cannabinoids, as it is virtually instantaneous.

We strongly advise against combustion processes, as the near-pyrolysis temperature of the furnace (400°C) will destroy the majority of terpenes (aromas and flavors) and eliminate 85% of inhaled cannabinoids.

The poor smoke generated will be composed of only 15% of active ingredients, supplemented by 85% of toxic compounds.

You will not enjoy the benefits of the beneficial molecules but will open the door to possible respiratory or cardiovascular complications caused by carbon monoxide, heavy metals and other tars.

Filtering the smoke through water will only have a comfort benefit: passing it through a cool liquid will at best cool it down and make it softer.

Vaporization, on the other hand, with its gentle induction or conduction heat of up to 220°C, will preserve the terpenes and most of the cannabinoids by vaporizing them, thus limiting any risk associated with combustion and smoking.

Ingestion will require an assimilation time of 30 minutes to over an hour, depending on body types, while dermal application of cosmetics in the form of creams, balms, and lotions will take one to two hours before the CBD penetrates the protective layers of the epidermis and begins to act on inflammation and muscle pain.

However, you may immediately feel the effects of associated pain-relieving ingredients such as capsaicin from peppers or phenols from green mint.

For long-lasting effects, ingestion with digestion of over an hour and slow release providing 4 to 8 hours of effects can be practical for organizing your schedule with time between intake and effects.

Sublingual ingestion provides a similar duration of effects, over 4 hours, but especially with faster action, its effectiveness will be felt in just 10 to 15 minutes.

01 - Bioavailability by Intravenous Route.

100% bioavailability rate, with immediate action.

02 - Bioavailability of Cosmetic Products.

Bioavailability rate 5-10%, with effects felt 1 to 2 hours after application for a durability of 1 to 2 hours.

They can be applied at your convenience.

03 - Bioavailability of Vaporizations.

Inhalation with its almost instantaneous action offers an effectiveness that will last only one to three hours but in return provides a much more interesting organoleptic journey.

04 - Oral bioavailability.

By ingestion: bioavailability 5 -20%, with effects felt 30 minutes to 2 hours after taking for a duration of 6 to 8 hours.

05 - Oral bioavailability.

By sublingual route: bioavailability rate 20-50%, with effects felt 10 to 15 minutes after taking for a duration of 4 to 6 hours.

What is water soluble CBD and how does it compare to CBD oil?

Due to the high water content of the human body, CBD which is also water soluble has ample space to disperse. The bioavailability, i.e. the amount of a substance absorbed by the body, is therefore much higher than in the case of CBD oil. CBD oil is considered to have a bioavailability of between 15-20%. How does the water solubility of CBD affect its bioavailability? There is currently no research from which to draw conclusions. However, from what we can gather from user feedback, the proportion is much higher - up to eight times more effective - than for conventional CBD oil.

What is the difference between absorption and bioavailability?

Understanding CBD Bioavailability

THE BIOAVAILABILITY OF CANNABIDIOL

In other words, bioavailability refers to the rate of effectiveness of a substance after administration, quantifying its availability and rate of uptake by body tissue or the bloodstream.

INGESTION OF CBD ALLOWS CANNABINOIDS TO BE INTRODUCED INTO THE DIGESTIVE SYSTEM AND LIVER TO BE CONVERTED INTO ASSIMILABLE FORM.

Endocannabinoid receptors have also been found in muscles and nerves, justifying the interest of certain cosmetic products used by dermal application.

We strongly advise against combustion processes

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THE DIFFERENT METHODS OF ADMINISTRATION OR ABSORPTION AND THEIR RATE OF AVAILABILITY.

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