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Understanding CBD Bioavailability

Sept 2022


The burgeoning market for CBD, driven by its growing popularity, has seen a wide range of products and usage options develop, as well as the emergence of scientific terms such as bioavailability, concentration and purity that can complicate consumer understanding and lead to mistakes in choice.


The proportion of CBD that the body assimilates is not only conditioned by the quantity and concentration of the products.
Another factor is bioavailability.
Bioavailability corresponds to the quantity and speed of passage of a molecule into the general bloodstream. In our case this molecule is the cannabidiol or CBD molecule.
Bioavailability is expressed as a percentage.

An intravenous injection is considered 100% bioavailable immediately.

In other words, bioavailability refers to the rate of effectiveness of a substance after administration, quantifying its availability and rate of uptake by body tissue or the bloodstream.

When CBD is introduced into the body, it is metabolized in different ways depending on how it has been administered.

Methods of administration such as ingestion, inhalation, or the application of cosmetics significantly influence the bioavailability rate, thereby altering the quantity of CBD that will ultimately need to be absorbed, the bioavailable amount.

Thus, the higher the bioavailability rate of a CBD product, the faster the effects will occur, and the less quantity will be required.
Medically, intravenous injection is considered 100% immediately bioaccessible.
Any other form of administration will be considered less available and will require larger quantities or higher concentrations.

Knowledge of bioavailability rates allows you to choose the most appropriate absorption method for your needs, precisely quantify the necessary doses, and optimize the dosage, leading to substantial savings.
CBD oil can be ingested in multiple ways, plain or in edibles or drinks.


They are then directed into the bloodstream.

But before this happens, a dialysis phenomenon occurs in the stomach, where metabolic enzymes perform filtration to eliminate chemical compounds and attempt to prevent the transfer of Cannabidiol into the bloodstream.

It also delays the assimilation of chemical compounds and the action of CBD, resulting in a slower release and delayed effects, which are more long-lasting.

The defensive reaction of our body destroys a portion of the molecules, requiring higher necessary doses.
By bypassing the digestive system, sublingual oil ingestion avoids these drawbacks and offers the highest bioavailability of all ingestion methods.

Choose between fast onset or later effects and duration of action of CBD effects.

Endocannabinoid receptors have also been found in muscles and nerves, justifying the interest of certain cosmetic products used by dermal application.

Precisely targeting specific areas, creams and lotions deliver active compounds to the nerves and muscles just beneath the skin, representing a growing trend in beauty and well-being.

However, cannabinoids, including CBD, being hydrophobic and the skin barrier significantly reducing their effectiveness, topical application undoubtedly provides the lowest bioavailability. When mixed with other essential oils, the synergy of all components will facilitate the dispersion and effectiveness of cannabinoids.

Finally, combustion-based inhalation methods, the least discreet, and vaporization, the most expensive, offer the highest absorption rate of cannabinoids, as it is virtually instantaneous.

Prefer CBD vaporization rather than combustion to fully enjoy the flavors and benefits of cannabidiol without harm to your health.

We strongly advise against combustion processes

We strongly advise against combustion processes, as the near-pyrolysis temperature of the furnace (400°C) will destroy the majority of terpenes (aromas and flavors) and eliminate 85% of inhaled cannabinoids.


The poor smoke generated will be composed of only 15% of active ingredients, supplemented by 85% of toxic compounds.

You will not enjoy the benefits of the beneficial molecules but will open the door to possible respiratory or cardiovascular complications caused by carbon monoxide, heavy metals and other tars.

Filtering the smoke through water will only have a comfort benefit: passing it through a cool liquid will at best cool it down and make it softer.

Vaporization, on the other hand, with its gentle induction or conduction heat of up to 220°C, will preserve the terpenes and most of the cannabinoids by vaporizing them, thus limiting any risk associated with combustion and smoking.


So, what is the minimum time needed for each method of consumption to feel the effects of your CBD product?
Everyone has their own way of consuming CBD, you will find at CBD-Fields a selection of the best range of CBD products.


Ingestion will require an assimilation time of 30 minutes to over an hour, depending on body types, while dermal application of cosmetics in the form of creams, balms, and lotions will take one to two hours before the CBD penetrates the protective layers of the epidermis and begins to act on inflammation and muscle pain.

However, you may immediately feel the effects of associated pain-relieving ingredients such as capsaicin from peppers or phenols from green mint.

For long-lasting effects, ingestion with digestion of over an hour and slow release providing 4 to 8 hours of effects can be practical for organizing your schedule with time between intake and effects.

Sublingual ingestion provides a similar duration of effects, over 4 hours, but especially with faster action, its effectiveness will be felt in just 10 to 15 minutes.


01 - Bioavailability by Intravenous Route.
100% bioavailability rate, with immediate action.

02 - Bioavailability of Cosmetic Products.
Bioavailability rate 5-10%, with effects felt 1 to 2 hours after application for a durability of 1 to 2 hours.
They can be applied at your convenience.

03 - Bioavailability of Vaporizations.
Inhalation with its almost instantaneous action offers an effectiveness that will last only one to three hours but in return provides a much more interesting organoleptic journey.

04 - Oral bioavailability.
By ingestion: bioavailability 5 -20%, with effects felt 30 minutes to 2 hours after taking for a duration of 6 to 8 hours.

05 - Oral bioavailability.
By sublingual route: bioavailability rate 20-50%, with effects felt 10 to 15 minutes after taking for a duration of 4 to 6 hours.
What is water soluble CBD and how does it compare to CBD oil?
Due to the high water content of the human body, CBD which is also water soluble has ample space to disperse. The bioavailability, i.e. the amount of a substance absorbed by the body, is therefore much higher than in the case of CBD oil. CBD oil is considered to have a bioavailability of between 15-20%. How does the water solubility of CBD affect its bioavailability? There is currently no research from which to draw conclusions. However, from what we can gather from user feedback, the proportion is much higher - up to eight times more effective - than for conventional CBD oil.
What is the difference between absorption and bioavailability?
Despite their frequent confusion, bioavailability and absorption refer to relatively distinct phenomena. When a cannabinoid enters the body, it passes through the mucous membranes that line the digestive system. This is the absorption phenomenon of CBD. However, bioavailability emphasizes the accessibility of Cannabidiol to the body as a whole, rather than to a specific organ or tissue.
How to increase the absorption rate of CBD in the body?
Combining CBD with high fat meals dramatically increases absorption.
Application creme cosmétique CBD Fields
Ingestion will require an assimilation time of 30 minutes to more than an hour depending on body type, while the administration by dermal application of cosmetics in the form of creams, balms and lotions will take one to two hours before the CBD penetrates the protective layers of the epidermis and begins to act on inflammation and muscle pain.
However, you may immediately feel the effects of associated pain-relieving ingredients such as capsaicin from chili peppers or phenols from spearmint.
For the durability of the effects, ingestion with its digestion of more than one hour and its slow diffusion providing 4 to 8 hours of effects can be practical to organize your schedule by having time between taking and effects.
Sublingual ingestion provides similar durability in terms of effects with more than 4 hours, but above all with a faster action, its effectiveness will be felt after only 10 to 15 minutes.