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Understanding CBD Bioavailability
Nicolas
CBD FIELDS
Sept 2022
Sept 2022
THE BIOAVAILABILITY OF CANNABIDIOL
The burgeoning market for CBD, driven by its growing popularity, has seen a wide range of products and usage options develop, as well as the emergence of scientific terms such as bioavailability, concentration and purity that can complicate consumer understanding and lead to mistakes in choice.
The proportion of CBD that the body assimilates is not only conditioned by the quantity and concentration of the products.
Another factor is bioavailability.
Bioavailability corresponds to the quantity and speed of passage of a molecule into the general bloodstream. In our case this molecule is the cannabidiol or CBD molecule.Bioavailability is expressed as a percentage.
An intravenous injection is considered 100% bioavailable immediately.
In other words, bioavailability refers to the rate of effectiveness of a substance after administration, quantifying its availability and rate of uptake by body tissue or the bloodstream.
When CBD is introduced into the body, it is metabolized in different ways depending on how it was administered.
Methods of administration such as ingestion, inhalation, or cosmetic application therefore greatly influence the rate of bioavailability, thereby altering the amount of CBD that will ultimately be absorbed: the bioavailable amount.
Thus, the higher the bioavailability of a product, the faster the effects will occur and the smaller the quantity needed to produce these effects.
Medically, an intravenous injection is 100% bioavailable immediately.
Any other form of administration will be considered less bioavailable and will require larger quantities or higher concentrations.
The knowledge of bioavailability rates allows you to choose the most appropriate absorption method for your needs, to precisely quantify the necessary doses and therefore to optimize the dosage, allowing substantial savings.
CBD oil can be ingested in multiple ways, plain or in edibles or drinks.
INGESTION OF CBD ALLOWS CANNABINOIDS TO BE INTRODUCED INTO THE DIGESTIVE SYSTEM AND LIVER TO BE CONVERTED INTO ASSIMILABLE FORM.
They are then directed to the bloodstream.
But first, a dialysis phenomenon occurs in the stomach, where metabolic enzymes filter out the chemical compounds and try to prevent the transfer of cannabidiol into the bloodstream.
Our body's defense reaction therefore destroys part of the molecules, requiring higher doses.
It also delays the assimilation of the chemical compounds and the action of CBD, resulting in slower diffusion and later but longer-lasting effects.
By bypassing the digestive system, sublingual oil ingestion avoids these drawbacks and offers the highest bioavailability of all ingestion methods.
Choose between fast onset or later effects and duration of action of CBD effects.
Endocannabinoid receptors have also been found in muscles and nerves, justifying the interest of certain cosmetic products used by dermal application.
Targeting specific areas, creams and lotions deliver active compounds to the nerves and muscles just beneath the skin and are a growing trend in beauty and wellness.
However, as cannabinoids are hydrophobic and the skin barrier significantly reduces their efficacy, dermal application is undoubtedly the method with the lowest bioavailability.
Then mixed with other essential oils, the synergy of these components will facilitate the diffusion and effectiveness of the cannabinoids.
Finally, inhalation by combustion, the least discreet method, and by vaporization, the most expensive method, have the highest absorption rate of cannabinoids, being almost instantaneous.
Prefer CBD vaporization rather than combustion to fully enjoy the flavors and benefits of cannabidiol without harm to your health.
We strongly advise against combustion processes
We strongly advise against combustion processes, as the near-pyrolysis temperature of the furnace (400°C) will destroy the majority of terpenes (aromas and flavors) and eliminate 85% of inhaled cannabinoids.
The poor smoke generated will be composed of only 15% of active ingredients, supplemented by 85% of toxic compounds.
You will not enjoy the benefits of the beneficial molecules but will open the door to possible respiratory or cardiovascular complications caused by carbon monoxide, heavy metals and other tars.
Filtering the smoke through water will only have a comfort benefit: passing it through a cool liquid will at best cool it down and make it softer.
Vaporization, on the other hand, with its gentle induction or conduction heat of up to 220°C, will preserve the terpenes and most of the cannabinoids by vaporizing them, thus limiting any risk associated with combustion and smoking.
So, what is the minimum time needed for each method of consumption to feel the effects of your CBD product?
Everyone has their own way of consuming CBD, you will find at CBD-Fields a selection of the best range of CBD products.
MINIMUM TIME TO FEEL THE EFFECTS OF YOUR CBD
Ingestion will require an assimilation time of 30 minutes to more than an hour depending on the morphology, whereas administration by dermal application of cosmetics in the form of creams, balms and lotions will take one to two hours before CBD penetrates the protective layers of the epidermis and begins to act on inflammation and muscle pain.
However, you may immediately feel the effects of the associated painkilling ingredients such as the capsaicin in chillies or the phenols in spearmint.
For the durability of the effects, ingestion with its digestion of more than an hour and its slow diffusion providing 4 to 8 hours of effects can be practical to help in dose planning by providing time between the intake and the effects.
THE DIFFERENT METHODS OF ADMINISTRATION OR ABSORPTION AND THEIR RATE OF AVAILABILITY.
01 - Bioavailability by Intravenous Route.
100% bioavailability rate, with immediate action.
02 - Bioavailability of Cosmetic Products.
Bioavailability rate 5-10%, with effects felt 1 to 2 hours after application for a durability of 1 to 2 hours.
They can be applied at your convenience.
03 - Bioavailability of Vaporizations.
Inhalation with its almost instantaneous action offers an effectiveness that will last only one to three hours but in return provides a much more interesting organoleptic journey.
04 - Oral bioavailability.
By ingestion: bioavailability 5 -20%, with effects felt 30 minutes to 2 hours after taking for a duration of 6 to 8 hours.
05 - Oral bioavailability.
By sublingual route: bioavailability rate 20-50%, with effects felt 10 to 15 minutes after taking for a duration of 4 to 6 hours.
Ingestion will require an assimilation time of 30 minutes to more than an hour depending on body type, while the administration by dermal application of cosmetics in the form of creams, balms and lotions will take one to two hours before the CBD penetrates the protective layers of the epidermis and begins to act on inflammation and muscle pain.
However, you may immediately feel the effects of associated pain-relieving ingredients such as capsaicin from chili peppers or phenols from spearmint.
For the durability of the effects, ingestion with its digestion of more than one hour and its slow diffusion providing 4 to 8 hours of effects can be practical to organize your schedule by having time between taking and effects.
Sublingual ingestion provides similar durability in terms of effects with more than 4 hours, but above all with a faster action, its effectiveness will be felt after only 10 to 15 minutes.
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