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CBD AND THE ENDO-CANNABINOID SYSTEM IN THE HUMAN BODY
UNDERSTAND EVERYTHING ABOUT THE INTERACTIONS BETWEEN
CBD BRAIN AND BODY.
NICOLAS
CBD FIELDS
OCT 2022
ACTION OF CBD IN THE HUMAN BODY
Historically, it was in 1940 that the first scientific research on hemp revealed the existence of cannabinoids and allowed the isolation of CBD and CBN.
THC, another cannabinoid from the same plant and famous for its psychoactivity, was later isolated by Professor Raphael Mechoulam in 1964.
Much research would follow in the medical world to identify the remaining hundred or so cannabinoids, to understand their interactions with the human body and to discover potential therapeutic effects.
But what is a cannabinoid?The term cannabinoid refers to all chemical compounds linked to the receptors of the human endocannabinoid system.
Two types are synthesised naturally. Laboratory synthesis of the third type has made great advances possible.
Endo-Cannabinoids are produced on demand and have a localized action.
The first type, therefore, includes the animal-type (endogenous)
The first type, therefore, includes the animal-type (endogenous) cannabinoids, the endo-cannabinoids, produced naturally by all species with a backbone.
They are an integral part of the Endo-Cannabinoid System (ECS), a kind of physiological communication system consisting of billions of receptors distributed throughout the body's cells.
Metabolised by the liver, endo-cannabinoids bind to these receptors, which regulate vital metabolic functions such as temperature or blood pressure.
They will eventually be broken down by enzymes and cannot be stored in the body as reserves.
They are therefore produced on demand and have a localised action.
The transformation into an assimilable form of CBD or Cannabidiol is absorption, not to be confused with bioavailability.
Ingestion of CBD allows the cannabinoids to be introduced into the digestive system and the liver to be transformed into an assimilable form.
The second type includes the plant-like (phytogenic) cannabinoids, Phyto-Cannabinoids, which are produced by plants
They do not only come from the cannabis genus, their presence having been discovered in truffles or Maca seeds for example.
Phytocannabinoids are fully compatible with our endo-cannabinoid receptors, so their action can modify or regulate certain physiological functions.
They can also supplement and fill endocannabinoid deficiencies through regular administration and allow homeostasis or balance of all body functions.
Endocannabinoid receptors have also been found in muscles and nerves, justifying the interest of certain cosmetic products used by dermal application.
The ECS system is characterized by receptors (locks), which can only be activated by the correct keys, the ligands. When a ligand (a key) binds to the receptor, the lock opens and triggers a signal that causes a specific biological effect.
ENDO CANNABINOID SYSTEM RECEPTORS
As for the receptors, the first type of receptors, called CB1, have functions such as appetite regulation or emotional processing.
They are present in the brain and central nervous system including the spinal cord, but also in the lungs, digestive system and genital system.
The second type, CB2 receptors, are found mainly in the immune system and organs such as the spleen, in the peripheral nervous system and in the skin.
Their main functions include the regulation and orchestration of inflammatory responses.
The SCE does everything in its power to maintain our internal harmony and improve our efficiency.
ECS helps us feel more comfortable when we experience feelings of anxiety.
The endocannabinoid system helps us feel better when we are depressed or in the grip of persistent depression.
Everything our internal network of neurotransmitters and receptors does serves the grand purpose of maintaining peak physical performance.
First of all, the ECS cannot function properly without the food and nutritional components that serve as its basis.
When functioning properly, the endocannabinoid system produces endocannabinoids in response to the body's specific needs.
When made, endocannabinoids interact with receptors in the endocannabinoid system (ECS).
When stimulated, neurons produce neurotransmitters, which in turn communicate with cells, tissues, organs and other vital body systems.
By destroying endocannabinoids as needed using enzymes, our body can maintain the endocannabinoid system in a state of homeostasis.
When the endocannabinoid system is functioning normally, the body's cells, tissues, and organs are all in sync, creating a state called homeostasis.
Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are the two main phytocannabinoids. In addition, there are over a hundred minor phytocannabinoids.
Cannabigerol (CBG), cannabidivarin (CBDV), cannabinol (CBN), cannabichromene (CBC) and tetrahydrocannabivarin (THCV) are among the best known (THCV).
There are many different types of phytocannabinoids, each with their own affinity and mechanism for binding to cannabinoid receptors.
Although research into phytocannabinoids like CBD and THC is expanding , very little is known about the vast majority of them.
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